Are there treatments to prevent or reverse Alzheimer's disease?
Sharp Again was founded in 2012 after we started to aggregate information about causes of memory loss and case studies of individuals who had regained their cognitive health.
Dr. Dale Bredesen of UCLA and the Buck Institute for Research on Aging published his first study in 2014. Since that time, evidence has been mounting that many of the causes of memory loss can be treated, especially in the early and mid-stages, by addressing some or many of the causes at the same time.
Here are the initial Bredesen studies plus several that followed.
Reversal of Cognitive Decline in Alzheimer’s Disease (2014)(pdf) Dale E. Bredesen, AGING, September 2014, Vol. 6 No.9 This report describes a novel, comprehensive, and personalized therapeutic program that is based on the underlying pathogenesis of Alzheimer’s disease, and which involves multiple modalities designed to achieve metabolic enhancement for neurodegeneration (MEND).
Reversal of Cognitive Decline in Alzheimer’s Disease (2016) (pdf) Dale E. Bredesen, Edwin C. Amos, Jonathan Canick, Mary Ackerley, Cyrus Raji, Milan Fiala, and Jamila Ahdidan, AGING, June 2016, Vol. 8 No.6 The results from quantitative MRI and neuropsychological testing in ten patients with cognitive decline, nine ApoE4+ (five homozygous and four heterozygous) and one ApoE4‐, who were treated with the MEND protocol for 5‐24 months.
The first phase of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) from 2009 – 2011, replicated many of the positive effects of the multi-therapeutic approach on cognition.